Matrix-bound extracellular vesicles encapsulated in collagen biomaterials for tissue-specific repair

Stem cells play a revolutionary role in tissue repair and regenerative medicine by offering the potential to self–renew, proliferate, and differentiate into specific cell types. This project investigates i) mesenchymal stem cell differentiation into bone, cartilage and fat and ii) the potential of extracellular vesicles isolated from the extracellular matrix (ECM-EVs) to drive tissue repair. Characterization and assessment of ECM-EVs’ cell-specific and therapeutic properties will be conducted to determine whether these extracellular vesicles can address challenges in resolving musculoskeletal tissue disorders. If successful, this study will clarify fundamental applications of ECM-EVs and inform new strategies for regenerative medicine.