Selective Retrosplenial Cortex Inhibition and Predictive Pursuit Behavior

The retrosplenial cortex (RSC), as shown through previous studies, is highly implicated in spatial learning and memory. Receiving inputs from areas including the anterodorsal thalamus, the subiculum, and the hippocampus, as well as the secondary motor cortex, the RSC may be the location of real-time sensory information’s integration with previous memory traces during predictive pursuit. This project aims to determine the integrative role the retrosplenial cortex plays in predictive pursuit behavior in rodents. By comparing global RSC inhibition with subiculum-specific efferent connections during a pursuit task, I hope to establish a direct link between the development of spatial learning shortcut behavior and the RSC.